_1694338160 20230910092920000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of Veterinary Physiology and Pathology J. Vet. Physiol. Pathol. 2821-0328 09 09 2023 2 3 Deny Jennes Deny Jennes Sudheesh S. Nair Aravind K. Unni Prasanna K. S. John Martin K. D. Introduction: Sebaceous gland adenitis is a rare condition found in large ruminants, eluding diagnosis and potentially progressing into neoplastic states if left untreated. The aim of the current study was to indicate the benefits of surgical excision of sebaceous gland adenitis in a Jersey crossbred cow.    Case report: A 6-year-old Jersey crossbred cow weighing 300 kg was admitted to the Teaching Veterinary Clinical Complex, Mannuthy, Thrissur, Kerala, India, in December 2022 with a soft tissue mass in the right vulval lip. Initially observed as a small skin bump, the condition had progressively worsened over 2 months, becoming an extensive mass contaminated with external debris and live maggots. Palpation revealed the mass to be firm without eliciting pain. The physiological parameters, such as rectal temperature, heart rate, and respiratory rate were within normal limits. The hematological and serum biochemical parameters were normal. The mass was resected surgically, and the vulval lip was reconstructed. Postoperatively, the cow received a 5-day course of enrofloxacin (Enro, India) at a dosage of 5 mg/kg body weight, along with 3 days of intramuscular meloxicam at a dosage of 0.2 mg/kg body weight and topical application of antiseptic ointment (Lorexane, India). The animal had an uneventful recovery after 2 weeks. Histopathological analysis confirmed the diagnosis as sebaceous gland hyperplasia and chronic adenitis. Conclusion: This study demonstrated that timely diagnosis and excision of the vulval tissue mass resulted in a complete recovery and preserved the animal's value. Chronic sebaceous gland adenitis may have a tendency to transform into a benign tumorous condition. The early presentation of the animal and successful surgical intervention prevented this transformation of sebaceous gland adenitis to a benign or malignant condition. 09 09 2023 47 51 https://creativecommons.org/licenses/by/4.0 10.58803/jvpp.v2i3.25 https://jvpp.rovedar.com/index.php/JVPP/article/view/25 https://jvpp.rovedar.com/index.php/JVPP/article/download/25/40 https://jvpp.rovedar.com/index.php/JVPP/article/download/25/40 Zachary JF. Pathologic basis of veterinary disease. 6th ed. St. Louis, Missouri: Elsevier; 2017. Available at: https://www.science direct.com/book/9780323357753/pathologic-basis-of-veterinary-disease#book-description 10.1111/1346-8138.13448 10.1111/ajd.12066 Max’s house. Tumors of the skin and subcutaneous tissues. 2005. 10.1111/j.1365-3164.2009.00807.x 10.1046/j.0959-4493.2001.00251.x Meuten DJ. Tumors in domestic animals. John Wiley & Sons; 2020. 10.1016/B978-072160558-6.50021-6 Parmar JJ, Al Shah AI, Rao N, Godasara DJ, and Patel DM. Successful surgical management of sebaceous gland tumors in dogs. Ind J Vet Sci and Biotech. 2019; 15: 78-80. Available at: https://acspublisher.com/journals/index.php/ijvsbt/article/view/2529 Kahn CM. The Merck Veterinary Manual. 9th ed. Merck & Co., Inc. 2005. Abrahamsen EJ. Chemical restraint in ruminants. Vet Clin 10.1016/j.cvfa.2008.02.005 10.1111/j.1365-2885.2010.01158.x 10.1136/vr.165.20.600 Plumb DC. Plumb’s veterinary drug handbook. 7th ed. Pharma Vet Inc; 2011. Suvarna KS, Layton C, and Bancroft JD. Bancroft’s theory and practice of histological techniques. 8th ed. Elsevier Health Sciences; 2018. 10.1016/0030-4220(93)90148-W Osborne C. Sebaceous adenitis in a 7 year old Arabian gelding. Can Vet J. 2006; 47(6): 583-586. PMID: https://pubmed.ncbi.nlm. nih.gov/16808233 10.1111/j.1365-3164.2010.00942.x 10.1136/bcr-2018-225655 10.1136/vr.156.19.612 Laiju PM, Deny J, Soumya R, Sudheesh NS, Syam VK, Praveen MK, et al. Unilateral conjunctival dermoid in a Holstein Friesian heifer. Indian J Vet Surg. 2021; 42(1): 68. Available at: https://www.indianjournals.com/ijor.aspx?target=ijor:ijvs&volume=42&issue=1&article=019