The Outbreak of Foot and Mouth Disease Serotype Sat-2 Infection in Al-Muthanna Province of Iraq
Main Article Content
Abstract
Introduction: prevalent in the majority of developing nations.
Case report: The present study reported a foot and mouth disease Sat-2 outbreak in Al-Muthanna province in southern Iraq in March 2023. Three male Holstein Friesian cows, aged between 1 and 1.5 years and weighing approximately 550 ± 15 kg each, were affected. Clinical examination revealed symptoms, including fever, severe lameness, anorexia, depression, frothy salivation, and vesicular lesions on the mouth and feet. Confirmation of the Sat-2 serotype was achieved through serological testing and genotyping of the virus, conducted by the FMD Institute, Ankara, Türkiye. The Sat-2 serotype was recognized by genotyping the virus and submitting SAT-2 VP1 sequences. The treatments for secondary infection prevention included Ceftifur (2.2 mg/kg) for 5 days, and flunixin meglumine (2.2 mg/kg) for 2 days. The other animals that were not exposed to infected animals were vaccinated against FMD. Rigorous biosecurity measures were implemented, involving thorough disinfection of the environment and quarantine of the infected animals. Direct contact between the farmer and other animals, particularly the sick ones, was completely avoided. After 2 weeks, all infected animals began to eat normally again, and clinical signs disappeared. Notably, other animals on the farm did not exhibit any signs of FMD.
Conclusion: In conclusion, the findings of this study underscore the importance of biosecurity measures and vaccination in FMD prevention. Additionally, administering antibiotics and non-steroidal anti-inflammatory drugs for the prevention of secondary infections proves to be crucial.
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References
Nikiforov V, Shcherbakov A, Chvala I, Kremenchugskaya S, Korennoy F, Mayorova T, et al. Insights into the molecular epidemiology of foot-and-mouth disease virus in Russia, Kazakhstan, and Mongolia in terms of O/ME-SA/Ind-2001e sublineage expansion. Viruses. 2023; 15(3): 598. DOI: 10.3390/v15030598
Garcia ML, and Romanowski V. Viral genomes. Rijeka: IntechOpen; 2012. Available at: 10.5772/1346
Grubman MJ, and Baxt B. Foot-and-mouth disease. Clin Microbiol Rev. 2004; 17(2): 465-493. DOI: 10.1128/cmr.17.2.465-493.2004
Carrillo C, Tulman ER, Delhon G, Lu Z, Carreno A, Vagnozzi A, et al. Comparative genomics of foot-and-mouth disease virus. J Virol. 2005; 79(10): 6487-504. DOI: 10.1128/jvi.79.10.6487-6504.2005
Longjam N, Deb R, Sarmah AK, Tayo T, Awachat VB, and Saxena VK. A brief review on diagnosis of foot-and-mouth disease of livestock: Conventional to molecular tools. Vet Med Int. 2011; 2011: 905768. DOI: 10.4061/2011/905768
Brito BP, Rodriguez LL, Hammond JM, Pinto J, and Perez AM. Review of the global distribution of foot and mouth disease virus from 2007 to 2014. Transbound Emerg Dis. 2017; 64(2): 316-332. DOI: 10.1111/tbed.12373
Xiao C, Rajput ZI, Liu D, and Hu S. Enhancement of serological immune responses to foot-and-mouth disease vaccine by a supplement made of extract of cochinchina momordica seeds. Clin Vaccine Immunol. 2007; 14(12): 1634-1639. DOI: 10.1128/CVI.00339-07
Arzt J, Juleff N, Zhang Z, and Rodriguez LL. The pathogenesis of foot-and-mouth disease I: Viral pathways in cattle. Transbound Emerg Dis. 2011; 58(4) :291-304. DOI: 10.1111/j.1865-1682.2011.01204.x
Mansour KA, Naser HH, and Hussain MH. Clinical, molecular detection and phylogenetic analysis study of local foot-and-mouth disease virus in Al-Qadisiyah province of Iraq. Vet World. 2018; 11(9): 1210-1213. DOI: 10.14202%2Fvetworld.2018.1210-1213
Sheikh MB, Rashid PA, Raheem Z, Marouf AS, and Amin KM. Molecular characterization and phylogenetic analysis of foot and mouth disease virus isolates in Sulaimani province, Iraq. Vet Res Forum. 2021; 12(2): 247-251. DOI: 10.30466%2Fvrf.2019.101755.2424
Abd Hatem A, Ahmed Abdul Wahid Al Anbagi N, Al-Alo KZK, and Sabah Bustani G. Detection of antibody against non-structural proteins of foot-and-mouth disease virus in cattle in Najaf,
Iraq. Arch Razi Inst. 2022; 77(3): 1185-1189. DOI: 10.22092/ARI.2022.357621.2074
Westren and Central Asia (WRLFMD). Republic of Iraq. 2023; Available at: https://www.wrlfmd.org/western-and-central-asia/iraq
Freath L, King D, Pacey A, and Bacigalupo S. Foot and mouth disease in the Middle East and North Africa. 2023; 2022: . Available
at: https://assets.publishing.service.gov.uk/government/ uploads /system/uploads/attachment_data/file/1135999/Foot_and_Mouth_Disease_in_the_Middle_East_and_North_Africa.pdf
Woldemariyam FT, Kariuki CK, Kamau J, De Vleeschauwer A, De Clercq K, Lefebvre DJ, et al. Epidemiological dynamics of foot-and-mouth disease in the Horn of Africa: The role of virus diversity and animal movement. Viruses. 2023; 15(4): 969. DOI: 10.3390/v15040969
World Reference laboratory for foot-and-mouth disease (WRLFMD). Foot-and-mouth disease January-March 2023 quarterly report. 2023.
p. 1-36. Available at: https://www.wrlfmd.org/sites/world/files/ quick_media/WOAH-FAO FMD Ref Lab Report Jan-Mar 2023.pdf
Alvi A, Javaid MK, Qamar W, Ahmed MH, and Ahmed A. Research article unusual case of foot and mouth disease in a ram (Ovis aries) in Pakistan and evaluation of symptomatic and supportive therapy. 2018; 7(3): 1342-1344. Available at: https://journalijcrls.com/ sites/default/files/issues-pdf/00937.pdf
World animal health information (WOAH). WAHIS portal: Animal health data. WAHIS events management, event 4856 Iraq – Foot and mouth disease virus. 2023. p. 1-3. Available at: https://wahis.woah.org/#/in-review/4856?reportId=158900&fromPage=event-dashboard-url
Lyons NA, Alexander N, Stärk KDC, Dulu TD, Rushton J, and Fine PE. Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya. Vet Res. 2015; 46(1): 41. DOI: 10.1186/s13567-015-0173-4
Radostits OM, Gay CC, Hinchcliff KW, Constable PD, Jacobs DE, Ikede BO, et al. Veterinary medicine: A textbook of the diseases of cattle, sheep, pigs, goats and horses. London: Elsevier Saunders; 2007. p. 966-994.
Gakuya DW, Mulei CM, and Wekesa SB. Use of ethnoveterinary remedies in the management of foot and mouth disease lesions in a diary herd. Afr J Tradit Complement Altern Med. 2011; 8(2): 165-169. DOI: 10.4314/ajtcam.v8i2.63204
Misk NA, Misk TN, and Rateb HZ. Assessment and topical treatment of lesions of foot and mouth disease in cattle. Assiut Vet Med J. 2015; 61(145): 75-81. DOI: 10.21608/avmj.2015.170185
Fakhrul-Islam KM, Shah Jalal M, Podder S, Quader N, Sahidur-Rahman, and Dutta A, et al. Short communication clinical investigation of foot and mouth disease of cattle in Batiaghata Upazilla veterinary hospital, Bangladesh. 2017; 2(3): 76-81. DOI: 10.17582/journal.vsrr/2016.2.3.76.81
Trif E, Cerbu C, Olah D, Zăblău SD, Spînu M, Potârniche AV, et al. Old antibiotics can learn new ways : A systematic review of florfenicol use in veterinary medicine and future perspectives using nanotechnology. 2023; 13(10): 1695. DOI: 10.3390/ani13101695
Ilott MC , Salt JS, and Gaskell RMKR. Dexamethasone inhibits virus production and the secretory IgA response in oesophageal – pharyngeal fluid in cattle persistently infected with foot-and-mouth disease virus. 1997; 181-187. DOI: https://doi.org/10.1017/S0950268896007376
Damaty HMEl, Fawzi EM, Neamat-allah ANF, Elsohaby I, Abdallah A, Farag GK, et al. Characterization of Foot and mouth disease virus serotype SAT-2 in swamp water buffaloes (Bubalus bubalis) under the Egyptian smallholder production system. 2021; 11(6): 1697. DOI: 10.3390/ani11061697
Apley MD. Clinical evidence for individual animal therapy for papillomatous digital dermatitis (hairy heel wart) and infectious bovine pododermatitis (foot rot). Vet Clin Food Anim Pract. 2015;31(1):81–95. https://doi.org/10.1016/j.cvfa.2014.11.009
Joshi V., VikramR., Chamuah J. K., Vupru K., Khate K. and Khan M.H. Foot and Mouth Disease (FMD) in Mithun: Clinical Presentation and Management. Technical Bulletin, ICAR-National Research Centre on Mithun, Nagaland. 2021.https://nrcmithun.icar.gov.in.