eng Rovedar Journal of Veterinary Physiology and Pathology 2821-0328 2025-09-15 4 3 39 45 10.58803/jvpp.v4i3.62 64 Habeeb Shakiru 0 https://orcid.org/0009-0007-7751-2708 Olawale Olawumi Ola 1 https://orcid.org/0000-0002-2698-7953 Monsuru Oladunjoye Tijani 1 https://orcid.org/0000-0001-9521-675X Theophilus Aghogho Jarikre 1 https://orcid.org/0000-0001-8222-198X Olanrewaju Samuel Olaifa 1 https://orcid.org/0009-0009-3682-8882 Abdulrauf Adekunle Usman 1 https://orcid.org/0009-0007-6614-6343 John Olurotimi Ajayi 2 https://orcid.org/0009-0007-4120-5431 Tola Felicia Ajani 0 https://orcid.org/0009-0002-1209-4094 Olumuyiwa Abiola Adejumobi 0 https://orcid.org/0000-0002-2165-9184 Temidayo Olutayo Omobowale 0 https://orcid.org/0000-0002-9486-2861 Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria Federal College of Animal Health and Production Technology, Moor Plantation, Ibadan, Oyo State, Nigeria Introduction: Vegetative valvular endocarditis is an uncommon but potentially fatal condition in dogs, often diagnosed post-mortem due to nonspecific clinical presentation and rapid progression. The present case report aimed to document the post-mortem and histopathological findings specific to bilateral valvular endocarditis with septic embolism-induced renal infarcts in a 9-year-old male Pit Bull. Case report: A 9-year-old male Pitbull presented with anorexia, exercise intolerance, recumbency, and a haemorrhagic scrotal mass. Clinical evaluation revealed hyperthermia, tachycardia, laboured respiration, and mitral regurgitation. The dog died despite intervention and was necropsied. Tissue samples taken from the heart, kidney, lungs, and liver were fixed in 10% buffered formalin, sectioned at 5 µm, and stained with haematoxylin and eosin. Endocardial samples were cultured on MacConkey and Blood agar. Necropsy revealed vegetative thrombotic endocarditis (Mitral valve), bronchopneumonia, renal infarctions, splenomegaly, and hindlimb myositis. Histology examinations confirmed fibrinous thrombi with bacterial colonies, pulmonary oedema, and hepatic chord atrophy, Kupffer cellular hyperplasia, and renal tubular thromboembolism and necrosis. Staphylococcus aureus and Klebsiella spp. were isolated from the endocardial samples and confirmed by Gram stain and biochemical tests such as catalase, indole, citrate, and oxidase tests. Conclusion: The present case demonstrated the systemic implications of canine valvular endocarditis, particularly its association with renal infarction and multi-organ pathology. Given the rarity of the condition, with an estimated prevalence of only 0.11% in dogs, the present report contributes to the expanding knowledge on understanding and managing similar cases in veterinary practice. https://jvpp.rovedar.com/index.php/JVPP/article/view/62 Dog Renal infarction Septic embolism Valvular endocarditis