eng Rovedar Journal of Veterinary Physiology and Pathology 2821-0328 2025-12-29 4 4 85 90 10.58803/jvpp.v4i4.63 65 Olawale Olatunde Modupeoluwa 0 https://orcid.org/0009-0001-6071-406X Billy Quadri Omoniyi 0 https://orcid.org/0009-0002-8262-1259 Abdulrauf Adekunle Usman 1 https://orcid.org/0009-0007-6614-6343 Taiwo Oluwatosin 0 https://orcid.org/0009-0007-1941-3576 Titilope Oluwatoyin Olagbegi 0 https://orcid.org/0000-0001-7799-9834 Bello Olaoluwa Isaac 0 https://orcid.org/0009-0001-6999-9559 Margaret Omotayo Owolabi 0 https://orcid.org/0009-0001-5126-6306 Olanrewaju Samuel Olaifa 1 https://orcid.org/0009-0009-3682-8882 Onyinye Ikejiofor 0 https://orcid.org/0009-0006-4510-3689 Tolulope Akin-fawole 0 https://orcid.org/0000-0002-0420-9261 Bello-Ibiyemi Abdulrahman Oluwatosin 0 https://orcid.org/0009-0003-4216-613X Department of Veterinary Services, Ministry of Agriculture and Food systems, Ikeja, Lagos state, Nigeria Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria Introduction: Spirochetes of Leptospira spp. are responsible for leptospirosis, a zoonotic bacterial infection that affects various animal species, particularly canines. The present study aimed to report the detailed clinical presentation, management, post-mortem examinations, and histopathological findings of a 5-year-old male Boerboel dog displaying signs of acute illness, including anorexia, constipation, and emesis. Case report: The dog was presented to the small animal clinic, Department of Veterinary Services, Ministry of Agriculture and Food Systems, Ikeja, Lagos State, Nigeria. Initial physical examinations revealed lethargy, pale mucous membranes, and constipation; laxatives and enemas were administered. The dog’s condition worsened, and then an exploratory laparotomy was performed, revealing a distended, obstructed intestine. Post-surgical care included antimicrobial and fluid therapy; however, the dog died a few days after the surgery. Necropsy revealed significant findings, including fatty liver, haemorrhagic enteritis, and lymphadenomegaly. Histopathological findings of the liver exhibited moderate hepatic lipidosis, inflammatory cell infiltration, and cholestasis. Renal samples exhibited interstitial nephritis and tubular degeneration. Reactive changes in gut-associated lymphoid tissues were observed in the intestinal samples. The polymerase chain reaction result for the Leptospira 16S rRNA gene was positive in the liver, confirming the diagnosis of canine leptospirosis. Conclusion: The present study highlighted the importance of timely diagnosis and intervention in suspected cases of leptospirosis. The combination of clinical assessment, post-mortem findings, histopathological evaluation, and molecular diagnostics provided a comprehensive understanding of the disease process and emphasized the need for increased awareness and improved management strategies for canine leptospirosis in veterinary practice. https://jvpp.rovedar.com/index.php/JVPP/article/view/63 Dog Kidney Leptospirosis Liver Pathology Polymerase chain reaction