_1759385551 20251002061231000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of Veterinary Physiology and Pathology J. Vet. Physiol. Pathol. 2821-0328 09 01 2025 4 3 Abayomi Kayode Olaifa https://orcid.org/0000-0003-2443-3866 Olanrewaju Samuel Olaifa https://orcid.org/0009-0009-3682-8882 Olugbenga O Alaka https://orcid.org/0000-0001-8319-1225 Omotayo Ayomikun Alaka https://orcid.org/0009-0008-9658-6881 Babatunde Olatunde Akanbi https://orcid.org/0000-0001-7719-2619 Richard Edem Antia https://orcid.org/0000-0002-5529-7521 Adedayo Ariyibi https://orcid.org/0000-0002-1812-5843 Introduction: Canine tumors cause significant morbidity and mortality, yet diagnostic methods in resource-limited settings remain inadequate. The present study assessed the pathological range and compared fine-needle aspiration cytology (FNAC) with histopathology to guide surgical and chemotherapeutic strategies in Veterinary Teaching Hospitals in Ibadan, Nigeria.Materials and methods: This retrospective study on suspected canine tumour cases (n=73) was collected from 2018 to 2025 across three veterinary centers in Ibadan, Nigeria. Clinical records were reviewed and data on demographics, tumour types, and diagnostic methods were systematically tabulated. Chi-square goodness-of-fit tests were employed to evaluate differences in age groups (middle-aged to geriatric), sex, diagnostic procedures such as FNAC and tissue biopsy, treatment modalities including surgical excision versus chemotherapy, and survival outcomes. Performance metrics of aspiration biopsy, comprising sensitivity, specificity, and predictive values, were calculated in comparison with histopathological findings. Furthermore, McNemar’s test was used to evaluate discordance between fine-needle cytology and biopsy results.Results: Age distribution was uneven, with the highest prevalence in 5-8-year-olds (30.1%). Male number was dominant (60.3%), but this difference was not statistically significant. Boerboels (37.0%) and German shepherds (30.1%) were more present than other breeds, suggesting possible breeder bias or increased breed-related tumor development. Tumor types included transmissible venereal tumors (21.9%), mammary tumors (13.7%), and lymphomas (9.6%). Use of diagnostic tools was different, with fine-needle cytology accounting for 45.2% and biopsy for 47.9% of procedures. Fine needle cytology had a sensitivity of 85% and specificity of 90%, with a positive predictive value of 92% and a negative predictive value of 81%, showing a nonsignificant difference with histopathology. Treatment approaches were different, with 61.6% receiving chemotherapy alone, 13.7% receiving both chemotherapy and surgery, 5.5% undergoing surgery only, and 19.2% receiving no treatment. The overall survival rate was 38.4%.Conclusions: The FNAC offered valuable initial information, whereas histopathology provides the definitive diagnosis. Implementing a stepwise diagnostic approach can facilitate more efficient utilization of limited resources, improve accuracy in prognostication, and ultimately enhance survival rates of dogs in Nigeria. 09 30 2025 46 52 https://creativecommons.org/licenses/by/4.0 10.58803/jvpp.v4i3.65 https://jvpp.rovedar.com/index.php/JVPP/article/view/65 https://jvpp.rovedar.com/index.php/JVPP/article/download/65/89 https://jvpp.rovedar.com/index.php/JVPP/article/download/65/89 10.3390/ani13091563 10.1111/vco.12208 10.21203/rs.3.rs-4502547/v1 10.20473/mkh.v36i1.2025.77-87 10.3390/vetsci11040175 10.1111/vco.12397 10.1371/journal.pone.0121268 10.1117/12.2256213 10.1371/journal.pone.0010822 10.5507/bp.2011.043 10.1002/dc.23976 10.1002/dc.21432 10.1159/000362805 10.3892/etm_00000100 10.1117/12.2654402 10.1007/s10637-011-9672-y 10.2460/javma.240.10.1181 10.4137/BMI.S5175 10.18316/rcd.v15i37.10920 10.3389/fvets.2022.843390 10.3892/or.2012.2014 10.1501/Vetfak_0000002738 10.29374/2527-2179.bjvm001422 Sanusi F, Olaifa OS, Usman AA, Samuel ES, Ariyibi A, Tiamiyu BK, et al. Pathological diagnosis and surgical management of oral squamous cell carcinoma in an 8-year-old German Shepherd dog: A case report. Anim Res Int. 2025; 22(2): 6274-6280. 10.32718/ujvas8-2.12 10.58803/saa.v4i1.37 10.1016/S2589-7500(23)00027-4