_1785389571 20260730053251000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of Veterinary Physiology and Pathology J. Vet. Physiol. Pathol. 2821-0328 06 04 2026 5 2 Deborah Maigawu Buba https://orcid.org/0000-0003-0910-7798 Iliya Paul Sambo https://orcid.org/0009-0002-9292-7761 Charibu Hurdison Dishon https://orcid.org/0009-0004-1769-7040 Emmanuel Vandi Tizhe https://orcid.org/0000-0002-0361-1902 George Yilzem Gurumyen https://orcid.org/0000-0001-6389-8573 Polycarp Nwunuji Tanko https://orcid.org/0000-0003-1459-2564 Asinamai Athliamai Bitrus https://orcid.org/0000-0002-8649-4798 Introduction: Bulbourethral gland disorders are rarely reported in cats, particularly in association with bacterial urinary tract infections. The present study described a case of bulbourethral gland enlargement in a domestic cat. Case report: A 2-year-old domestic short-haired tom cat weighing 4.7 kilograms presented to the Veterinary Teaching Hospital, University of Jos, Jos, Plateau State, Nigeria, with a major complaint of dysuria, vomiting, and inappetence. The clinical evaluation revealed lymphadenopathy, bladder distension, and haematuria. Radiographic findings demonstrated bilateral renomegaly and a distended urinary bladder. The duration of study and therapy was three days. Despite supportive therapy, including 10 mg piroxicam at 0.3 mg/kg intramuscular (IM), lactated Ringer's at 4 mL/kg, 10 mg of furosemide at 2 mg/kg, IM, 2 mg of dexamethasone at 0.2 mg/kg, IM, and 5 mg of metoclopramide at 0.2 mg/kg, IM, the animal died on the third day after presentation, and post-mortem examination revealed marked enlargement of the bulbourethral glands. Bacteriological cultures of blood, urine, and kidney samples yielded isolates of both Proteus mirabilis and Escherichia coli from each sample. Histopathological examination demonstrated glandular hyperplasia with inflammatory cell infiltration in the bulbourethral gland, lungs, and heart muscle. Conclusion: The present study highlighted the potential role of opportunistic bacterial pathogens in the pathogenesis of bulbourethral gland enlargement and underscored the importance of early diagnosis and intervention in feline lower urinary tract disease. 06 28 2026 https://creativecommons.org/licenses/by/4.0 10.58803/jvpp.v5i2.93 https://jvpp.rovedar.com/index.php/JVPP/article/view/93 https://jvpp.rovedar.com/index.php/JVPP/article/download/93/123 https://jvpp.rovedar.com/index.php/JVPP/article/download/93/123 10.1016/j.jfms.2007.06.003 10.1177/1098612X19880435 10.2460/javma.1991.199.02.211 10.46419/vs.55.6.8 10.1111/j.1748-5827.2005.tb00288.x 10.29244/avl.7.3.43-44 10.3390/ani15152235 10.1136/vr.104440 10.2754/avb201988040433 10.1016/j.rvsc.2025.105695 Nikousefat Z, Hashemnia M, Javdani M, and Ghashghaii A. 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